imageConventional design and development efforts for medical devices largely focus on establishing the biocompatibility and mechanical stability of materials. Although computational models are widely used to predict device performance for regulatory purposes, these models largely neglect the complex multi-physics environment, which is dictated by the interaction between biological cells and tissues with body fluids. Furthermore cells and tissues respond to biophysical stimuli imposed by medical devices and these responses are fundamental to long-term performance, but remain poorly understood. As a result the ability to control such responses through innovative device design has not yet been fully harnessed. Prof. McNamara’s research group have provided computational approaches that can simulate interactions between deformable biological structures, adjacent fluid flows and medical devices. Her group collaborate with medical device partners (Boston Scientific, Stryker Instruments, Medtronic) to apply their computational methods to understand the design of next generation medical devices. They also collaborate with companies to provide fundamental understanding of the response of bone cells to the physical environment imposed by medical devices.