Bone and cartilage tissue are bearing daily loads and the body. Throughout the life-time, they are altered. My aim is to contribute to research with a nearby clinical application. During her thesis, her research focus was on the build-up of a stratified scaffold based on alginate laden with human mesenchymal stem cells from bone marrow. The objective was to develop an original strategy to repair defect in the full depth of articular cartilage up to the sub-chondral bone and checked the mechanical behaviour of the scaffold to be secure to have one with suitable strength for articular cartilage defects.
During her first post-doc, the goal was to used nano- or microfibrous scaffolds (approved by the FDA) to fill bone and osteochondral defects to accelerate the tissue regeneration by adsorbing growth factors and/or seeding human mesenchymal stem cells on the biomaterial.
Now, she is working on bone mechanobiology in the specific way of osteoporosis. This disease will affect quite the half of women in their life with an increasing after menopausal. The aim is to make the link between the mechanical behaviour of bone compartments at different scales and biological pathway already know to have links with cell sensing capacity. Finally, we could found how to prevent osteoporosis with already know pharmaceutical drugs.