Ivor Geoghegan (PhD)

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Ivor Geoghegan was awarded a Science degree from NUI Galway in 2011. He worked for two years in the medical device sector (Lake Region Medical) before returning to NUI Galway to complete the MSc in Biomedical Science at NUI Galway. He is undertaking a PhD in Biomedical Engineering entitled “Investigations into bone and cartilage cell mechanosensory mechanisms” under the supervision of Dr. Laoise McNamara in the Mechanobiology Research Group in the Discipline of Biomedical Engineering and in collaboration with Dr. David Hoey at Trinity College Dublin.

Abstract:

Ivor is now undertaking a PhD in Biomedical Engineering entitled “Investigations into bone and cartilage cell mechanosensory mechanisms” under the supervision of Dr. Laoise McNamara. This project involves the characterisation of mechanosensory mechanisms and mechanobiological responses of bone cells derived from healthy and diseased tissues. These studies will involve bioreactor studies, in vitro cell and tissue culture, histology and biological analysis (immunohistochemistry, RT-PCR) to measure mechanotransduction responses. A particular focus will be to delineate whether changes in mechanosensitive organelles occur during bone diseases, and identify changes in the biochemical signal transduction pathways in response to mechanical loading in diseased tissues. Such information will inform therapeutic interventions that modulate the mechanotransduction process e.g. alter extracellular matrix molecules, mechanoreceptors, cytoskeletal structures or biochemical signalling, and may provide an effective therapy for bone diseases. This research will also inform the use of medical device interventions that disrupt the in vivo mechanical environment.

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