Wejdan Alansary is a 2nd year PhD student in Biomedical Engineering. In 2013, she completed MSc in Biomedical Science from National University of Ireland Galway. Wejdan has attained BSc in Science and Education with a Major in Biology form Umm Al-Qura University. In 2011, Wejdan was awarded a scholarship sponsored by The Higher Ministry of Saudi Arabia under King Abdullah Program, to pursue her PhD in National University of Ireland Galway. Her ongoing PhD research is based on The Role of Primary Cilia for Bone Mechanotransduction during Osteoporosis. This research involved comparing the morphology of primary cilia under normal and osteoporotic conditions. Currently, she is investigating the gene expression involved in primary cilia that may be associated with osteoporotic conditions, along with the application of mechanical stimulation.
Bone adaptation relies on osteocyte cells that appraise the mechanical environment and elicit a biochemical signalling response to initiate tissue adaptation when the mechanical environment is not favourable. Primary cilia (PC) have recently been proposed to play an important role in facilitating osteocyte mechanosensation. However it is not yet known whether PC expression or function is altered in mechanoregulatory osteocytes during the disease of osteoporosis. This research seeks to understand whether expression of PC is altered during osteoporosis using both in vitro and in vivo approaches. In-vitro studies involving bone marrow stromal cells and osteoblasts are being conducted to examine the response of these cells to mechanical stimulation with and without primary cilia.