Bone tissue engineering and regenerative medicine are promising strategies for treating bone diseases and reconstructing bone defects. For many years research has been dedicated to understanding the biochemical environment that is required to encourage bone regeneration and the desired properties of biocompatible scaffold materials. These studies demonstrate the potential for stem cell based therapies for bone regeneration. However the field of tissue regeneration is faced with the specific challenge to develop novel tissue regeneration approaches to produce tissue that can simultaneously support loading, but is also porous to allow for cell migration and diffusion of nutrients into the regenerated tissue to maintain viability. Prof. McNamara’s research group develop mechanobiology based approaches (compression, vibration, fluid flow and hydrostatic bioreactors) for bone tissue regeneration and apply these methods to overcome limitations of biomaterial based in vitro approaches for bone tissue regeneration.